Scuola Internazionale Superiore di Studi Avanzati de Trieste

SISSA Front Building

SISSA, the International School of Advanced Studies, was founded in 1978 and is a scientific center of excellence within the national and international academic scene. Located in Italy, in the city of Trieste, it features 82 professors, 97 post-docs, 283 PhD students and 114 technical administrative staff. 


Neuron Physiology and Technology Lab
At Neuron Physiology and Technology Lab, in SISSA (Trieste) our aim is to investigate the biological processes influenced by nanomaterials and nanomaterials interaction with biological membranes. The goal is to develop a new generation of multifunctional implantable materials targeted to the treatment/repair, for example, of spinal cord lesion. By the convergence among different fields like nanotechnologies, polymer science and neurophysiology research, we test nanostructure-bio-hybrid synthetic implants in cultured hippocampal neuronal networks to address multiple key design criteria, such as biocompatibility, bioactivity and electrical conductivity. The morphology of neuronal networks interfaced to nanomaterials is reconstructed by scanning electron microscopy (SEM) or confocal microscopy while patterns of activity is measured by single and multiple electrophysiological measures or by calcium-imaging.

Figure_2 Neuronal network.


Figure_1 Electrophysiology system.


Figure_3 Neuronal cells.


laura Prof. Laura BalleriniExperiments strategy design and project coordination.

 

denis Dr. Denis Scaini Material technologies and experiments strategy and design.

rossana Dr. Rossana Rauti In vitro experiments: dissociated neuronal cells and organotypic slices morphological and functional characterization.

ivo Dr. Ivo Calaresu In vivo experiments: cortical implants, behavioral studies, dissociated neuronal cells and organotypic slices morphological and functional characterization.

manuela Dr. Manuela Medelin In vivo experiments: cortical implants, behavioral studies, dissociated neuronal cells and organotypic slices morphological and functional characterization.

sadaf Dr. Sadaf Usmani In vivo experiments: spinal implants and behavioral studies.

riccardo Dr. Riccardo Redivo Project’s costs management, administrative coordination, dissemination, missions, orders.